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Sensibilisation ou allergie PDF
By:Ouafeh Ghazouani
Published on 2013 by


L'allergie à l'arachide est la troisième cause d'allergie alimentaire chez l'enfant de moins de trois ans et la première dépassé cet âge. Parfois qualifiée d'épidémie, l'allergie à l'arachide a une prévalence estimée à 0,3-0,75 % dans la population française. Contrairement aux autres allergies alimentaires qui ont tendance à guérir avec l'âge, l'allergie à l'arachide persiste. Le diagnostic repose sur l'interrogatoire du patient et/ou de sa famille, les tests cutanés et le test de provocation orale. Le clinicien dispose aussi d'outils biologiques comme le dosage des immunoglobulines e spécifiques qui utilise soit des extraits de l'aliment suspecté ou des allergènes moléculaires. Nous avons évalué l'apport du profil de sensibilisation moléculaire dans une population de 244 patients d'origine méditerranéenne. Les résultats montrent que les enfants sont le plus souvent sensibilisés à Ara h 2 (69 %) puis à Ara h 1 (57,5 %) et enfin à Ara h 9 (52 %). Le rapport des IgE anti-Ara h 2 par les IgE anti-extrait de l'arachide est le meilleur moyen pour prédire une allergie à l'arachide. Chez les adultes Ara h 9 prédomine (52 %). La combinaison de Ara H 2 et de Ara h 9 est le meilleur moyen pour prédire une allergie.

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